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Ion Pair Chromatography Reagents

Ion Pair Chromatography Reagents

The use of ion-pairing reagents as mobile phase additives allows the separation of ionic and highly polar substances on reversed phase HPLC columns. The purity of mobile phase additives is of utmost importance to their successful application. CDH offers an outstanding range of tailor-made reagents All mobile phase additives are subject to rigorous testing with special emphasis on the requirements of modern reversed phase HPLC.

Ion Pair Chromatography & Electronic Grade Chemicals products are especially designed for pharmaceutical applications. Ion pair chromatography is a method used to separate charged elements. It is broadly utilized to selectively analyze bases and acids and, especially with reverse stage chromatography. An ion pair chemical is added to modulate holding of the ionic analytes. Typical Ion Pair chemical s are: tetra-alkylammonium, alkylsulphates, alkylsulphonates ions, etc.

IPC (Ion Pair Chromatography) is a more applicable and general formulation that allows the separation of complicated combinations of ionic and polar molecules. The property is determined by the mobile form: the organic eluent is supplemented with a particular ion-pairing chemical agent. The Ion Pair Chromatography Chemical Agents are huge ionic particles having a charge differently to the analyte of interest, as well as a hydrophobic part to act with the stationary or fixed stage.

Our electronic grade chemicals are conforming to international standards and have very low level metal impurities and guarantee the best action of the final products.

The ions of the eluent combines with the counter-ion, becoming ion pairs in the fixed stage. This shows many effects in various retention, thus helping separation of analytes. Ion Pair Chromatography is now a known and reliable method which provides:

  • Extremely reproducible outcomes
  • Decreased separation times
  • Simultaneous modification of non-ionized and ionized analytes in one run
  • Sharper peak shapes
  • Broad selection of additives to boost separation
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